Ai-Li Shiau
Oct-3/4 (also known as Oct-4, Oct-3 and POU5f1), a member of the POU family, is an octamer-binding transcription factor that is a key regulator in undifferentiated, pluripotent cells including human embryonic stem cells and germ cells. Oct-3/4 has been demonstrated to be a sensitive and specific immunohistochemical marker of gonadal germ cell tumors, specifically seminoma and embryonal carcinoma. …