Wen-Chang Chang
Lipopolysaccharide (LPS), which is present in the outer layer of the cell wall in gram-negative bacteria, induces innate immune responses via toll-like receptor (TLR)-4 and is recognized by monocytes/macrophages. LPS is associated with many neurodegenerative diseases, including Alzheimer's disease, multiple sclerosis, and amyotrophic lateral sclerosis (1-3). In the central nervous system (CNS), …